Repression of cytochrome P450- dependent hydrohylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione- dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
Matyushin B. N., Loginov A. S., Tkachev V. D. (1997) Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases. Voprosy Meditsinskoi Khimii, 43(4), 256-260.
Matyushin B. N. et al. Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 4. - P. 256-260.
Matyushin B. N. et al., "Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases." Voprosy Meditsinskoi Khimii 43.4 (1997): 256-260.
Matyushin, B. , N., Loginov, A. , S., Tkachev, V. , D. (1997). Cytochrome P450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in patients with chronic liver diseases. Voprosy Meditsinskoi Khimii, 43(4), 256-260.
