Monoamine oxidase (MAO) is an integral protein of the outer mitochondrial membrane, catalysing the reaction of oxidative deamination of monoamines in the central nervous system and peripheral tissues. The present paper reviews data on the structure of MAO, approaches and methods of computer modeling of active site structure, based on the analysis of MAO inhibition by selective inhibitors Flexible molecules, possessing many conformers are useless for computer modeling. Competitive fully reversible MAO inhibitors with rigid structure and limited number of conformers are preferential compounds for these studies.
Veselovsky A.V., Ivanov A.S., Medvedev A.E. (1997) Use of selective inhibitors for computer modeling of the monoamine oxidase active site . Voprosy Meditsinskoi Khimii, 43(6), 527-536.
Veselovsky A.V. et al. Use of selective inhibitors for computer modeling of the monoamine oxidase active site // Voprosy Meditsinskoi Khimii. - 1997. - V. 43. -N 6. - P. 527-536.
Veselovsky A.V. et al., "Use of selective inhibitors for computer modeling of the monoamine oxidase active site ." Voprosy Meditsinskoi Khimii 43.6 (1997): 527-536.
Veselovsky, A. V., Ivanov, A. S., Medvedev, A. E. (1997). Use of selective inhibitors for computer modeling of the monoamine oxidase active site . Voprosy Meditsinskoi Khimii, 43(6), 527-536.
References
Gorkin V.Z. Amine Oxidase in Clinical Research. 1983. Pergamon Press. Oxford. Scholar google search
Cerusa A.N., Pletscher A.//'Prog. Drug Res. 1992. V. 38. P. 171-297. Scholar google search
Shih J. In: Monoamine Oxidase: basic and clinical aspects; Yasuhara H., Parvez S. H., Oguchi K., SandierM, Nagatsu T. Eds; VSP: Utrecht, 1993, P. 15-22. Scholar google search
Bach A. W. J., Lan N. C, Johnson D. L, Abell С W., Bembeneck M. E., Kwan S. W., Seeburg P. H., Shih J. H. //Proc. Natl. Acad. Sci. 1988, 85, P. 4934-4938. Scholar google search
Wu K, Chen K., Shin J.C. II Mol.Pharmacol. 1993. V. 43. P. 888-893. Scholar google search
Him I., Tsugeno Y., Ogata F, ho A. II J. Biochem. 1996. V. 120. P. 759-765. Scholar google search
Gottowik J, Malherbe P., Lang G., Daprada M, Cesttra A.M. II Eur.J. Biochem. 1995. V. 230. P. 934-942. Scholar google search
Chen K., Wu H.F., Shih J.C. II J.Neurochem. 1996.V. 66. P. 797-803. Scholar google search
Grimsby J., Zentner, M., Shih, J.C. II Life.Sci. 1996. V. 58. P. 777-787. Scholar google search
Wouters J., Ramsay R., Goormaghtigh E., Ruysschaert J.M., Brasseur R., Durant F. II Biochem.Biophys.Res.Commun. 1995. V. 208. P. 773-778. Scholar google search
Zeller E.A., Arota K.L., Gurne D.H., Huprikar S.V. In: Monoamine Oxidase: Structure, function and Altered Function. Eds. Singer T.P., Von Korff R.W., Murphy D.L. 1979, P. 101-120. Academic Press. New York. Scholar google search
Maret G., Tayar N. E., Carnipl P. A., Testa В., Jenner P., Baird M. II Biochem. Pharmacol. 1990. V. 40. P. 783-792.
