The following changes were found in children in the minimal cerebral dysfunction: the hypoaminoacidemia and hypoaminoaciduria with decrease of glutamate and aspartate, their amides, methionine and serine in the blood and urine; decrease of lysine, taurine, tyrosine, catecholamines and serotonin in the blood; increase of GABA and glycine in the blood; increase of xanthurenate, proline and cysteine in the urine. The ratio excitatory/inhibitory mediatory amino acids decreased significantly. The ratio essential/nonessential amino acids and concentrations of amino acids, transporting by x-AG, beta and A/ASC systems, decrease in the blood; majority of transporting systems in the kidney functions augmently. Disturbances of amino acids metabolism disappear or decrease in successful treatment.
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Keywords: amino acids and their metabolites, cerebral dysfunction
Citation:
Kolesnishenko L.S., Kulinsky V.I., Gorina A.S. (1999) Amino acids and their metabolites in blood and urine in the minimal cerebral dysfunction. Voprosy Meditsinskoi Khimii, 45(1), 58-64.
Kolesnishenko L.S. et al. Amino acids and their metabolites in blood and urine in the minimal cerebral dysfunction // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 1. - P. 58-64.
Kolesnishenko L.S. et al., "Amino acids and their metabolites in blood and urine in the minimal cerebral dysfunction." Voprosy Meditsinskoi Khimii 45.1 (1999): 58-64.
Kolesnishenko, L. S., Kulinsky, V. I., Gorina, A. S. (1999). Amino acids and their metabolites in blood and urine in the minimal cerebral dysfunction. Voprosy Meditsinskoi Khimii, 45(1), 58-64.
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