Variation of fructose 2,6-bisphosphate (F-2,6-P2) content in the peripheral blood lymphocytes of patients with diabetes mellitus (type II) was investigated. The 2.5-fold increase of F-2,6-P2 level compared with to the control group was observed in untreated patients with early stage of the disease. In patients using of peroral antidiabetic drugs that corrected diabetes F-2,6-P2 level was approached to the normal one. At the same time F-2,6-P2 content decreases in patients with severe (noncorrected) diabetes mellitus. The possible mechanisms of regulation of lymphocyte F-2,6-P2 concentration in normal conditions and diabetes mellitus are discussed.
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Keywords: fructose 2,6-bisphosphate, lymphocytes, diabetes mellitus, protein kinase C
Citation:
Korovkin B.F., Belayeva N.F., Kraevoy C.A., Golubev M.A., Gorodetsky V.K., Markova M.S., Kolchenko O.L. (1999) Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus. Voprosy Meditsinskoi Khimii, 45(3), 232-237.
Korovkin B.F. et al. Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus // Voprosy Meditsinskoi Khimii. - 1999. - V. 45. -N 3. - P. 232-237.
Korovkin B.F. et al., "Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus." Voprosy Meditsinskoi Khimii 45.3 (1999): 232-237.
Korovkin, B. F., Belayeva, N. F., Kraevoy, C. A., Golubev, M. A., Gorodetsky, V. K., Markova, M. S., Kolchenko, O. L. (1999). Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus. Voprosy Meditsinskoi Khimii, 45(3), 232-237.
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