The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.
Golubev M.A., Gorodetsky V.K., Aniskina A.P., Tochilkin A.I., Belyaeva N.F. (2000) The comparison study of vanadium-compounds with insulin-mimetic properties. Voprosy Meditsinskoi Khimii, 46(2), 155-161.
Golubev M.A. et al. The comparison study of vanadium-compounds with insulin-mimetic properties // Voprosy Meditsinskoi Khimii. - 2000. - V. 46. -N 2. - P. 155-161.
Golubev M.A. et al., "The comparison study of vanadium-compounds with insulin-mimetic properties." Voprosy Meditsinskoi Khimii 46.2 (2000): 155-161.
Golubev, M. A., Gorodetsky, V. K., Aniskina, A. P., Tochilkin, A. I., Belyaeva, N. F. (2000). The comparison study of vanadium-compounds with insulin-mimetic properties. Voprosy Meditsinskoi Khimii, 46(2), 155-161.
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