The effect of intravenous administration of lactate dehydrogenase (5000 E/kg) on some metabolic parameters was investigated. The hyperenzymemia was accompanied by changes of metabolite content (glutamate, 2-oxoglutarate, lactate, dihydroxyacetone phosphate) and enzyme activities (aldolase, lactate dehydrogenase, transaminase) in heart, liver and skeletal muscles. Intravenously administered tritiated lactate dehydrogenase was preferentially found in skeletal muscles, liver, kidneys and some other organs.
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Gilmiyarova F.N., Radomskaya V.M., Kretova I.G., Kleiman M.S., Pervova Yu.V. (2001) Role of hyper lactate dehydrogenazemia in induction of metabolic disturbance inorganism. Voprosy Meditsinskoi Khimii, 47(5), 469-476.
Gilmiyarova F.N. et al. Role of hyper lactate dehydrogenazemia in induction of metabolic disturbance inorganism // Voprosy Meditsinskoi Khimii. - 2001. - V. 47. -N 5. - P. 469-476.
Gilmiyarova F.N. et al., "Role of hyper lactate dehydrogenazemia in induction of metabolic disturbance inorganism." Voprosy Meditsinskoi Khimii 47.5 (2001): 469-476.
Gilmiyarova, F. N., Radomskaya, V. M., Kretova, I. G., Kleiman, M. S., Pervova, Yu. V. (2001). Role of hyper lactate dehydrogenazemia in induction of metabolic disturbance inorganism. Voprosy Meditsinskoi Khimii, 47(5), 469-476.
Walsh D.A., Parkins J.P., Krebs E. (1968) J. Biol. Chem., 243, 3763- 3765. Scholar google search
Beeckmans S., Kanasek E. (1996) Organ Cell Metabolism: Proc. NATO Alv. Res. Work- Shop, Hensthelis. - New York - London, 199- 208. Scholar google search
Прохорова М.И. (1982) Методы биохимических исследований Л., 168- 171. Scholar google search
Chee P.Y., Dahl J.L., Pahien L.A. (1979) J. Neurochem., 33, N 1, 53- 60. Scholar google search
Horecker B.L., Tsolas O., Lai C.Y. (1972) The Enzymes. - New- York. 7, 213. Scholar google search
Bergmeyer H. (1962) Methoden der enzymatischen analyse. - Weinheiru. Scholar google search
Гильмиярова Ф.Н., Радомская В.М., Виноградова Л.Н. (1986) Инструкция по применению унифицированных клинических лабораторных методов исследования. М. Scholar google search
Lowy O.H., Rosebrough N., Farr A., Randal R. (1951) J. Biol. Chem., 193 , 265- 275. Scholar google search
Гильмиярова Ф.Н., Радомская В.М., Виноградова Л.Н. и др. (1984) Авторское свидетельство № 356234 «Способ получения ферментов». Scholar google search
