Different types of hypoxic preconditioning (hypoxic, circulatory, hemic and tissue hypoxia) increase the tolerance to complete global cerebral ischemia at early terms (hours). Biochemico-pharmacological analysis with the use of selective agonists and antagonists showed the importance of adenosine A1-receptors and K+ATP-channels in the mechanisms of the neuroprotective effect and natural tolerance. The general scheme of the investigated mechanisms of different types of hypoxic preconditioning has been proposed.
Kulinsky V.I., Gavrilina T.V., Minakina L.N., Kovtun V.Yu. (2006) Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice. Biomeditsinskaya Khimiya, 52(3), 309-316.
Kulinsky V.I. et al. Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice // Biomeditsinskaya Khimiya. - 2006. - V. 52. -N 3. - P. 309-316.
Kulinsky V.I. et al., "Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice." Biomeditsinskaya Khimiya 52.3 (2006): 309-316.
Kulinsky, V. I., Gavrilina, T. V., Minakina, L. N., Kovtun, V. Yu. (2006). Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice. Biomeditsinskaya Khimiya, 52(3), 309-316.
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