Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases
Maltsev A.V.1 , Galzitskaya O.V.2
1. Russian Gerontological Research Clinical Center, Russian Ministry of Health Care
Institute of Biological Instrumentation, Russian Academy of Sciences 2. Insitute of Protein Research, Russian Academy of Sciences, Pushchino
Studies of neurodegenetrative disorders have become particularly actual attracting the attention of researchers from over the world because of the dissemination of Alzheimer's disease. The reason for such pathogenesis is the transition of a "healthy" molecule or peptide from the native conformation into a very stable "pathological" isoform. During this, molecules in the "pathological" conformation aggregate, forming amyloid fibrils that can increase without any control. Novel knowledge is required on sporadic isoforms of Alzheimer's disease, on the nature of triggering mechanisms of conformational transitions of beta-amyloid fragments from normally functioning proteins into new formations - nano-beta-amyloids - that spiral out of control of neurons and organism which leads to the loss of neurons. Herein we review studies devoted to the formation of amyloid fibrils and their role in pathogenesis of amyloid diseases.
Maltsev A.V., Galzitskaya O.V. (2010) Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases. Biomeditsinskaya Khimiya, 56(6), 624-638.
Maltsev A.V. et al. Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases // Biomeditsinskaya Khimiya. - 2010. - V. 56. -N 6. - P. 624-638.
Maltsev A.V. et al., "Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases." Biomeditsinskaya Khimiya 56.6 (2010): 624-638.
Maltsev, A. V., Galzitskaya, O. V. (2010). Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases. Biomeditsinskaya Khimiya, 56(6), 624-638.
Figueredo-Pereira M.E., Efthimiopoulos S., Tezapsidis N., Buku A., Ghiso J., Mehta P., Robakis N.K. (1999) J. Neurochem., 72(4), 1417-1422. CrossRef Scholar google search
Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X.D., McKay D.M., Tintner R., Frangione B., Younkin S.G. (1992) Science, 258(5079), 126-129. CrossRef Scholar google search
Sokolik V.V., Maltzev A.V. (2008) Fourth International Interdisciplinary Congress `Neuroscience for Medicine and Psychology`, Sudak, Crimea, Ucraine. June 10-20, pp. 278-280. Scholar google search
Maddalena A.S., Papassotiropoulos A., Gonzalez-Agosti C., Signorell A., Hegi T., Pasch T., Nitsch R.M., Hohk C. (2004) Neurodegener. Dis., 1(4-5), 231-235. CrossRef Scholar google search
Ghiso J., Shayo M., Calero M., Ng D., Tomidokoro Y., Gandy S., Rostagno A., Frangione B. (2004) J. Biol. Chem., 279(44), 45897-45908. CrossRef Scholar google search
