In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats.
Gorodetskii V.K. et al. Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV) // Biomeditsinskaya Khimiya. - 2011. - V. 57. -N 1. - P. 133-137.
Gorodetskii V.K. et al., "Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)." Biomeditsinskaya Khimiya 57.1 (2011): 133-137.
Gorodetskii, V. K., Tochilkin, A. I., Belayeva, N. F., Kovelman, I. R., Korovkin, B. F. (2011). Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV). Biomeditsinskaya Khimiya, 57(1), 133-137.
