Mitochondrial disfunction in Parkinson's disease

Buneeva O.A.; Medvedev A.E.

doi:10.18097/PBMC20115703246

Mitochondrial disfunction in Parkinson's disease

Buneeva O.A.¹, Medvedev A.E.¹

1. Institute of Biomedical Chemistry

Section: Review

DOI: 10.18097/PBMC20115703246 PubMed Id: 21863741

Year: 2011 Volume: 57 Issue: 3 Pages: 246-281

Mitochondrial structural and functional abnormalities in Parkinson's disease and experimental animal models of this pathology are described. Special attention is paid to the inactivation of mitochondrial enzymes, mutations in mitochondrial and nuclear DNA, and genomic and proteomic research of mitochondrial proteins in Parkinson's disease and experimental parkinsonism of animals.

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Keywords: Parkinson`s disease, mitochondria, mitochondrial enzymes, genomics, proteomics

Citation:

Buneeva, O. A., Medvedev, A. E. (2011). Mitochondrial disfunction in Parkinson's disease. Biomeditsinskaya Khimiya, 57(3), 246-281.

This paper is also available as the English translation: 10.1134/S1990750811040032

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