1. I.M. Sechenov First Moscow State Medical University, Research Center 2. Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
Peoples` Friendship University of Russia, Ecological Faculty 3. National Research Center of Antibiotics
Telomerase is a ribonucleoprotein that synthesizes telomeric repeats and identified as a promising target for anticancer therapy. Here we describe a new compound aITEL1296 as a potent telomerase inhibitor. Its inhibitory activity was a bit higher (IC50 = 0,19±0,02 ng/ml) than that of BIBR1532, one of the most potent telomerase inhibitors known to date. Besides telomerase inhibition aITEL1296 activated apoptotic mechanisms and effectively suppressed proliferation of tumor cell lines (GI50 = 5,0±0,2 ng/ml for most sensitive cell line LnCap) but not normal fibroblast cell line.
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Keywords: telomerase, telomere, aITEL1296, inhibitor, cancer cells, apoptosis
Citation:
Kovalenko N.A., Zhdanov D.D., Bibikova M.V., Gotovtseva V.Y. (2011) The influence of compound itel1296 on telomerase activity and the growth of cancer cells. Biomeditsinskaya Khimiya, 57(5), 501-510.
Kovalenko N.A. et al. The influence of compound itel1296 on telomerase activity and the growth of cancer cells // Biomeditsinskaya Khimiya. - 2011. - V. 57. -N 5. - P. 501-510.
Kovalenko N.A. et al., "The influence of compound itel1296 on telomerase activity and the growth of cancer cells." Biomeditsinskaya Khimiya 57.5 (2011): 501-510.
Kovalenko, N. A., Zhdanov, D. D., Bibikova, M. V., Gotovtseva, V. Y. (2011). The influence of compound itel1296 on telomerase activity and the growth of cancer cells. Biomeditsinskaya Khimiya, 57(5), 501-510.
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