Peculiarities of the circulating phagocytes functional activityin patients with different forms of drug-resistant pulmonary tuberculosis

Titarenko O.T.; Dyakova M.E.; Esmedlyaeva D.S.; Pavlova M.V.; Yielkin A.V.; Alekseeva N.C.; Bondarenko B.B.

doi:10.18097/PBMC20125804467

Peculiarities of the circulating phagocytes functional activityin patients with different forms of drug-resistant pulmonary tuberculosis

Titarenko O.T.¹, Dyakova M.E.¹, Esmedlyaeva D.S.¹, Pavlova M.V.¹, Yielkin A.V.¹, Alekseeva N.C.¹, Bondarenko B.B.¹

1. Research Institute of Phtysiopulmonology

Section: Experimental/Clinical Study

DOI: 10.18097/PBMC20125804467 PubMed Id: 23413691

Year: 2012 Volume: 58 Issue: 4 Pages: 467-474

Functional activity of circulating phagocytes (macrophages - Ms and neutrophils - Ns) was studied in 30 patients with infiltrative (I) and 30 patients with fibro-cavernous (FC) pulmonary tuberculosis (PT). Difference of the functional activity of both types of cells depending on the PT form was revealed: more significant increase in the oxygen-depending activity in FCPT while bactericide potential estimated with a zymosane induced NST-test was more pronounced in IPT patients. These data correlate with the blood levels of neopterin and elastase, the markers of the M and N activity, respectively. Participation of intracellular ADA in realization of oxygen-depending processes was demonstrated. Results of the multivariant analysis of the whole complex of the studied phagocyte characteristics, reflect their different roles in ther pathological process a prevailing role of Ms in the firstly diagnosed acute tuberculosis process (IPT) and Ns in the chronic progressive process (FCT).

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Keywords: tuberculosis, drug-resistant, phagocyte activity, NST-test, adenosine deaminase, neopterin

Citation:

Titarenko, O. T., Dyakova, M. E., Esmedlyaeva, D. S., Pavlova, M. V., Yielkin, A. V., Alekseeva, N. C., Bondarenko, B. B. (2012). Peculiarities of the circulating phagocytes functional activityin patients with different forms of drug-resistant pulmonary tuberculosis. Biomeditsinskaya Khimiya, 58(4), 467-474.

This paper is also available as the English translation: 10.1134/S1990750811030152

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