The review briefly summarizes information of structure of integrins and their involvement in the development and malignant progression of tumors. Special attention is paid to approaches based on modification of functional properties of integrins that prevent/antagonize tumor growth and progression; these approaches developed in modern experimental biology have certain perspective in clinical application.
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Keywords: structure and function of integrins, integrin-specific immune preparations, peptide-based integrin antagonists, anti-cancer therapy
Citation:
Berman A.E., Kozlova N.I., Morozevich G E. (2013) Integrins as a potential target for targeted anticancer therapy. Biomeditsinskaya Khimiya, 59(3), 239-248.
Berman A.E. et al. Integrins as a potential target for targeted anticancer therapy // Biomeditsinskaya Khimiya. - 2013. - V. 59. -N 3. - P. 239-248.
Berman A.E. et al., "Integrins as a potential target for targeted anticancer therapy." Biomeditsinskaya Khimiya 59.3 (2013): 239-248.
Berman, A. E., Kozlova, N. I., Morozevich, G, E. (2013). Integrins as a potential target for targeted anticancer therapy. Biomeditsinskaya Khimiya, 59(3), 239-248.
Eble J.A. (1997) in: Molecular biology intelligence unit. Integrin-ligand interaction (Eble J.A., Kunn K., eds). Chapman and Hall, NewYork., pp. 1-40. CrossRef Scholar google search
