Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus
Reikhardt B.A.1 , Shabanov P.D.1
1. Institute of Experimental Medicine, St. Petersburg, Russia
Protein kinase CK2 is an important enzyme in the nervous system. The nuclear forms of CK2 regulate chromatin structure and gene expression, the key processes for long-term memory formation. Memory modulators, the Structural Analogues of Etimizole (SAE), were able to increase or decrease the activity of chromatin-associated CK in the cortex and hippocampus of rat brain in vitro. In vivo memory enhancers from SAE-group (3 mg/kg) stimulated CK2 activity and the transcriptional ability of chromatin in the cortex and hippocampus, starting from 30 min with a peak for 60 min and a duration up to 180 min. At these periods the memory inhibitor from the SAE-group reduced CK2 activity and chromatin transcription. It is assumed that the modulating effect of SAE on CK2 activity and transcription underlies the effects of these compounds on long-term memory.
Download PDF:
Keywords: brain, long-term memory, chromatin, transcription, protein phosphorylation, protein kinase CK2
Citation:
Reikhardt B.A., Shabanov P.D. (2020) Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus. Biomeditsinskaya Khimiya, 66(2), 130-137.
Reikhardt B.A. et al. Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus // Biomeditsinskaya Khimiya. - 2020. - V. 66. -N 2. - P. 130-137.
Reikhardt B.A. et al., "Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus." Biomeditsinskaya Khimiya 66.2 (2020): 130-137.
Reikhardt, B. A., Shabanov, P. D. (2020). Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus. Biomeditsinskaya Khimiya, 66(2), 130-137.
