The study of saliva composition attracts much attention and the number of publications in this area is constantly growing. However, the impact individual factors on saliva composition still needs better understanding. The limited use of saliva as a biological fluid for clinical laboratory diagnostics is determined by the lack of standardized preanalytical methods and the absence of reference values for biochemical parameters that take into account a number of factors affecting saliva composition and properties. In this review we have analyzed some factors influencing saliva composition. The impact of these factors on saliva composition is associated with dysfunction of the salivary glands, changes in salivation rate, salivary viscosity, dry mouth, pH balance, and electrolyte composition, leading to impaired homeostasis of the oral cavity.
Sarf E.A., Bel`skaya L.V. (2025) Factors of variability in the composition of mixed saliva (a review). Biomeditsinskaya Khimiya, 71(5), 319-332.
Sarf E.A. et al. Factors of variability in the composition of mixed saliva (a review) // Biomeditsinskaya Khimiya. - 2025. - V. 71. -N 5. - P. 319-332.
Sarf E.A. et al., "Factors of variability in the composition of mixed saliva (a review)." Biomeditsinskaya Khimiya 71.5 (2025): 319-332.
Sarf, E. A., Bel`skaya, L. V. (2025). Factors of variability in the composition of mixed saliva (a review). Biomeditsinskaya Khimiya, 71(5), 319-332.
References
Kochurova E.V., Kozlov S.V. (2014) The diagnostic possibilities of saliva. Russian Clinical Laboratory Diagnostics, 59(1), 13–15. Scholar google search
Hamilton K.R., Granger D.A., Taylor M.K. (2022) Science of interdisciplinary salivary bioscience: history and future directions. Biomark. Med., 16(14), 1077–1087. CrossRef Scholar google search
Raimkulova Ch.A., Aronbaev S.D., Aronbaev D.M. (2022) Measurement the pH of mixed saliva using a potentiometric flow-injection sensor. Universum: Khimiya i Biologiya, 6(96), 5–12. CrossRef Scholar google search
Krahel A., Hernik A., Dmitrzak-Weglarz M., Paszynska E. (2022) Saliva as diagnostic material and current methods of collection from oral cavity. Clin. Lab., 68(10), 4278. CrossRef Scholar google search
Frid P., Halbig J.M., Alstergren P., Berstad J.R., Cetrelli L., Feuerherm A.J., Flatø B., Rosen A., Rosendahl K., Rygg M., Rypdal V., Songstad N.-T., Tømmerås B., Nordal E., Al-Haroni M. (2025) Cytokines in saliva, serum, and temporomandibular joint synovial fluid in children with juvenile idiopathic arthritis: an explorative cross-sectional study. Pediatr. Rheumatol. Online J., 23(1), 66. CrossRef Scholar google search
Zhao X., Chen X., Zhou Z., Zheng J., Lin Y., Zheng Y., Xu R., Hu S., Cui L. (2025) Advancements and challenges in salivary metabolomics for early detection and monitoring of systemic diseases. MedComm, 6, e70395.
