1. Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, Москва, Россия 2. Федеральный исследовательский центр оригинальных и перспективных биомедицинских и фармацевтических технологий, Москва, Россия
Изатин (индол-2,3-дион) — эндогенный регулятор, присутствующий в организме человека и животных. Благодаря способности взаимодействовать с многочисленными белками-мишенями, изатин демонстрирует широкий спектр биологической активности, в том числе проявляет нейропротекторное действие в моделях болезни Паркинсона (БП) у грызунов с использованием нейротоксинов МФТП (1-метил-4-фенил-1,2,3,6- тетрагидропиридина) и ротенона. Антипсихотический препарат галоперидол, нарушая баланс нейромедиаторов в нигростриатном пути, моделирует дефицит дофамина и способствует развитию двигательных нарушений, свойственных БП. В данной работе исследовали действие двух доз изатина (10 мг/кг и 80 мг/кг) на индуцированную галоперидолом каталепсию и на протеомный профиль мозга мышей. Предварительное введение изатина (за 1 ч до введения галоперидола) снижало выраженность галоперидоловой каталепсии. Введение галоперидола и изатина совместно с галоперидолом оказывало влияние на относительное содержание ряда белков, ассоциированных с БП и другими нейродегенеративными заболеваниями.
Бунеева О.А., Капица И.Г., Завьялова М.Г., Калошина С.А., Згода В.Г., Медведев А.Е. (2026) Влияние нейропротектора изатина на индуцированную галоперидолом каталепсию и протеомный профиль мозга мышей. Биомедицинская химия, 72(4), 267-278.
Бунеева О.А. и др. Влияние нейропротектора изатина на индуцированную галоперидолом каталепсию и протеомный профиль мозга мышей // Биомедицинская химия. - 2026. - Т. 72. -N 4. - С. 267-278.
Бунеева О.А. и др., "Влияние нейропротектора изатина на индуцированную галоперидолом каталепсию и протеомный профиль мозга мышей." Биомедицинская химия 72.4 (2026): 267-278.
Бунеева, О. А., Капица, И. Г., Завьялова, М. Г., Калошина, С. А., Згода, В. Г., Медведев, А. Е. (2026). Влияние нейропротектора изатина на индуцированную галоперидолом каталепсию и протеомный профиль мозга мышей. Биомедицинская химия, 72(4), 267-278.
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