Mass-spectrometric MRM analysis of FDA-verified proteins in the blood plasma of healthy volunteers

Novikova S.E., Farafonova T.E., Tikhonova O.V., Shushkova N.A., Pyatnitsky M.A., Zgoda V.G., Ponomarenko E.A., Lisitsa A.V., Grigoryev A.I., Tutelyan V.A., Archakov A.I.

Year: 2020 Vol: 66 Issue: 4 Pages: 294-316


Supplementary materials:   RUEN
Monitored transitions for the targeted mass spectrometric MRM assay; MRM results for 148 peptides mapped onto 111 FDA-verified proteins that were measured in 31 experimental samples; significance in clinical laboratory medicine; examples of MRM signal for proteins of the blood plasma proteomic core with the highest biological variability; lists of proteins of the blood plasma proteomic core, proteins that were variably detected and missing proteins; examples of MRM signal for proteins that were variably detected in blood plasma.PBMC-2020-66-4-294_S.zip