Screening of potential non-azole inhibitors of lanosterol14-alpha demethylase (CYP51) of Candida fungi

Kaluzhskiy L.A., Ershov P.V., Yablokov E.O., Mezentsev Y.V., Gnedenko O.V., Shkel T.V., Gilep A.A., Usanov S.A., Ivanov A.S.

Year: 2021 Vol: 67 Issue: 1 Pages: 42-50

Supplementary materials:   RUEN
The possible orientation of haloperidol in the active site of CYP51 Candida albicans. Diagram of physicochemical properties of haloperidol derivatives. An alignment of CYP51 amino acid sequences of Candida albicans and Candida glabrata as well as yeast from the class Saccharomyces. The prediction of the orientation of haloperidol structural derivatives in complexes.PBMC-2021-67-001-42-S.pdf  PBMC-2021-67-001-42-S.pdf