Master regulators associated with poor prognosis in glioblastoma multiforme

Kalya M.P., Beisbarth T., Kel A.

Year: 2021 Vol: 67 Issue: 3 Pages: 201-212

Supplementary materials:   RUEN
TCGA samples clinical information. Normalized and batch corrected TCGA-GBM microarray data. Univariate survival analysis for TCGA(N=560) data. Full list of TRANSPATH ® 2021.1 enriched pathways. Full list of REACTOME enriched pathways. List of transcription factors enriched in the promoters of genes having significant impact upon survival in GBM. List of 43 potential feedback-loop-controlled master regulators. Differential gene expression analysis between extreme survivor groups. Master regulators identified in the study along with their differential expression values across extreme survivor groups. PCA plot for the normalized and batch corrected (N=560) TCGA-GBM data. Composite model of transcription factors identified. The Heatmap of the expression values of 43 master-regulator