Simultaneous inhibition of mTOR and STING as an approach to reduce alpha-synuclein and lysosphingolipid levels in peripheral blood monocytederived macrophages and the SH-SY5Y cell line: implications for therapy of Parkinson’s disease
Bezrukova A.I., Basharova K.S., Galkina E.S., Epifanivskaya O.S., Baydakova G.V., Zakharova E.Yu., Pchelina S.N., Usenko T.S.Year: 2026 Vol: 72 Issue: 1 Pages: 42-61
| Supplementary materials: | RU | EN |
| Data on the assessment of the dose-dependent effect of the mTOR kinase activity inhibitor Torin1, the STING protein inhibitor H-151 and their combination on the activity of mTOR signaling and STING signaling, the degree of autophagy, the activity of lysosomal hydrolases, the concentration of lysosphingolipids, the level of various forms of alpha-synuclein protein and the degree of apoptosis in the primary culture of macrophages and the SH-SY5Y neuroblastoma cell line. |