1. Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет), Москва, Россия 2. Тюменский государственный университет, Тюмень, Россия 3. Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет), Москва, Россия; Московский государственный университет имени М.В. Ломоносова, Москва, Россия
Бактериальные инфекции являются серьёзной причиной высокой заболеваемости и смертности во всём мире. За последние десятилетия лекарственная устойчивость бактериальных патогенов неуклонно возрастает, в то время как скорость разработки новых эффективных антибактериальных препаратов остаётся стабильно невысокой. Царство растений иногда называют бездонным колодцем для поиска новых средств противомикробной терапии. Это связано с тем, что растения легкодоступны и дёшевы в переработке, а экстракты и компоненты растительного происхождения часто демонстрируют высокий уровень биологической активности при незначительных побочных эффектах. Многообразие полученных из растительного сырья соединений способно обеспечить весьма широкий выбор разнообразных химических структур для взаимодействия с различными мишенями внутри бактериальной клетки, а стремительное развитие современных биотехнологических инструментов открывает путь к направленному получению биоактивных компонентов с желаемыми свойствами. Задачей данного обзора стал ответ на вопрос, имеют ли шанс противомикробные препараты растительного происхождения сыграть роль панацеи в борьбе с инфекционными заболеваниями в “эпоху пост-антибиотиков”.
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Ключевые слова: вторичные метаболиты растений (ВМР), фитопроизводные, лекарственная устойчивость, бактериальные патогены, антимикробные свойства
Цитирование:
Нестерович В.М., Белых Д.А., Гороховец Н.В., Курбатов Л.К., Замятнин А.А., Икрянникова Л.Н. (2023) Вторичные метаболиты растений и их возможная роль в “эпоху супербактерий”. Биомедицинская химия, 69(6), 371-382.
Нестерович В.М. и др. Вторичные метаболиты растений и их возможная роль в “эпоху супербактерий” // Биомедицинская химия. - 2023. - Т. 69. -N 6. - С. 371-382.
Нестерович В.М. и др., "Вторичные метаболиты растений и их возможная роль в “эпоху супербактерий”." Биомедицинская химия 69.6 (2023): 371-382.
Нестерович, В. М., Белых, Д. А., Гороховец, Н. В., Курбатов, Л. К., Замятнин, А. А., Икрянникова, Л. Н. (2023). Вторичные метаболиты растений и их возможная роль в “эпоху супербактерий”. Биомедицинская химия, 69(6), 371-382.
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