Implication of integrin α5β1 in human breast carcinoma apoptosis and drug resistance

Morozevich G.E.1, Kozlova N.I.1, Ushakova N.A.1, Preobrazhenskaya M.E.1, Berman A.E.1

1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20115701077      PubMed Id: 21516779
Year: 2011  Volume: 57  Issue: 1  Pages: 77-84
Doxorubicin-resistant MCF-7Dox line, which is a derivative of the drug-sensitive MCF-7 human breast carcinima line, differs from the latter by a strongly reduced expression of the α2β1 integrin and a highly increased expression of the α5β1 receptor. Silencing of this integrin in the MCF-7Dox cells by transfection with α5-specific siRNA markedly stimulated anoikis and increased sensitivity of the cells to doxorubicin. α5β1 silencing also leads to significant inhibition of the activity of kinases Akt and Erk2 in MCF-7Dox cells. Our results suggest that integrins α5β1-induced signals, controlling distinct aspects of cell behavior, are conducted through the common signal pathways.
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Keywords: integrins, anoikis, drug resistance, signal protein kinases

Morozevich, G. E., Kozlova, N. I., Ushakova, N. A., Preobrazhenskaya, M. E., Berman, A. E. (2011). Implication of integrin α5β1 in human breast carcinoma apoptosis and drug resistance. Biomeditsinskaya Khimiya, 57(1), 77-84.
This paper is also available as the English translation: 10.1134/S1990750811030085
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