Extracellular vesicles for diagnosis and therapy of gliomas: problems and opportunities

Filin A.A.1 , Chernysheva A.A.1, Pavlova G.V.2, Loshhenov V.B.3, Gurina O.I.1

1. V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia
2. Institute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia
3. Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20226806419      PubMed Id: 36573408
Year: 2022  Volume: 68  Issue: 6  Pages: 419-426
Glioblastoma is a primary brain tumor and one of the most aggressive malignant neoplasms. The prognosis remains poor with a short survival period after diagnosis even in the case of timely detection and early treatment with the use of advanced chemotherapy, radiation therapy and surgical treatment. In this regard, the research of the main pathogenetic links in the glioblastoma development continues. The current focus is on studying the molecular characteristics of tumours, including the analysis of extracellular vesicles, which play an essential role in intercellular communication processes. In this review, in order to provide up-to-date information on the role of extracellular vesicles in the diagnosis and therapy of gliomas, the analysis of the achieved results of Russian and foreign research related to this area has been carried out. The main goal of this review is to describe the features of extracellular vesicles as the containers and glioma marker transporters, as well as nucleic acids used in diagnosis and therapy.
Download PDF:  
Keywords: glioma, biomarkers, extracellular vesicles, miRNA, diagnosis, therapy

Filin, A. A., Chernysheva, A. A., Pavlova, G. V., Loshhenov, V. B., Gurina, O. I. (2022). Extracellular vesicles for diagnosis and therapy of gliomas: problems and opportunities. Biomeditsinskaya Khimiya, 68(6), 419-426.
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)