Two schemes of the treatment of chronic hepatitis C were compared. Each scheme included 40 medical treatment for 2 months. 22 patients received basic therapy including phosphogliv, 3-5 procedures of ultraviolet irradiation of blood (UVIB) and roferon (the course was begun after the 2-nd procedure of UVIB). 18 patients received basic therapy with phosphogliv, UVIB and T-activin (the course also was begun after the second procedure of UVIB). The patients were observed for 9 months. An advantage of the combination of phosphogliv, UVIB and roferon, providing a stable remission in 36,3% of the patients for 9 months was demonstrated.