Nitric oxide production in organs of pregnant mice (liver, kidney, placenta) was measured using specifical NO traps, Fe-dithiocarbamate complexes (Fe-DETC) forming with NO paramagnetic mononitrosyl iron complexes with DETC (MNIC-DETC), detected by EPR method (-196°C).
The amount of NO formed increased in dependence of the pregnancy period (from the first to the third trimesters). Addition of NO-synthase substrate, L-arginine, insignificantly influenced endogenous NO production. However, endogenous NO amount sharply decreased at experimental acute renal failure.
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Burgova E.N., Murashko A.V., Murashko L.E., Serezhenkov V.A., Vanin A.F. (2003) Peculiarities of nitric oxide production after pregnancy and experimental acute renal failure. Biomeditsinskaya Khimiya, 49(1), 12-18.
Burgova E.N. et al. Peculiarities of nitric oxide production after pregnancy and experimental acute renal failure // Biomeditsinskaya Khimiya. - 2003. - V. 49. -N 1. - P. 12-18.
Burgova E.N. et al., "Peculiarities of nitric oxide production after pregnancy and experimental acute renal failure." Biomeditsinskaya Khimiya 49.1 (2003): 12-18.
Burgova, E. N., Murashko, A. V., Murashko, L. E., Serezhenkov, V. A., Vanin, A. F. (2003). Peculiarities of nitric oxide production after pregnancy and experimental acute renal failure. Biomeditsinskaya Khimiya, 49(1), 12-18.
