Peculiarities of nitric oxide production after pregnancy and experimental acute renal failure

   
Burgova E.N.1 , Murashko A.V.2, Murashko L.E.2, Serezhenkov V.A.1 , Vanin A.F.1

1. Semenov Institute of Chemical Physics RAS
2. Russian Center of Obstetrics, Gynecology and Perinatology RAMS
Section: Experimental/Clinical Study
PubMed Id: 14569869
Year: 2003  Volume: 49  Issue: 1  Pages: 12-18
Nitric oxide production in organs of pregnant mice (liver, kidney, placenta) was measured using specifical NO traps, Fe-dithiocarbamate complexes (Fe-DETC) forming with NO paramagnetic mononitrosyl iron complexes with DETC (MNIC-DETC), detected by EPR method (-196°C). The amount of NO formed increased in dependence of the pregnancy period (from the first to the third trimesters). Addition of NO-synthase substrate, L-arginine, insignificantly influenced endogenous NO production. However, endogenous NO amount sharply decreased at experimental acute renal failure.
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Burgova E.N., Murashko A.V., Murashko L.E., Serezhenkov V.A., Vanin A.F. (2003) Biomeditsinskaya khimiya, 49(1), 12-18.
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