Experimental study of functional activity neutrophiles and macrophages followed effect produced by sodium nitrite

   
Deryagina V.P.1, Mashkovcev Yu.V.1, Ilnitsky A.P.1

1. Cancer Research Center, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
PubMed Id: 14569870
Year: 2003  Volume: 49  Issue: 1  Pages: 19-26
The impact of sodium nitrite on functional activity of macrophages and neutrophiles of the abdominal cavity and blood of mice BALB/c was investigated in vitro and in vivo experiments. Functional activity was estimated according to formation of oxigen active forms. It was shown that sodium nitrite significantly inhibits formation of reactive oxygen species released from mouse peritoneal neutrophiles and macrophages, when they are being activated in vitro. Sodium nitrite was given in water at concentration 500,0 mg/l mice for 210 days immunodepression action was revealed which expressed reduction by leukopoes and decrease functional activity of blood neutrophils. Under the same conditions nitrite did not effect on functional activity of resident peritoneal macrophages.
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Deryagina V.P., Mashkovcev Yu.V., Ilnitsky A.P. (2003) Biomeditsinskaya khimiya, 49(1), 19-26.
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