This review is devoted to the role of low molecular weight antioxidants and antioxidant enzymes in cancerogenesis. The data are analyzed on accumulation of lipid-soluble and water-soluble antioxidants in a number of malignant human and experimental tumors especially in the renal cell carcinoma tissues. A possibility is discussed concerning the pro- and anticancerogenic effects of the abundant tumor content of antioxidants. Implication of antioxidants in tumor resistance to chemotheraputic drugs and ionazing radiation is discussed as well.
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Nikiforova N.V., Berman A.E. (2003) Antioxidants in malignant human and experimental tumors. Biomeditsinskaya Khimiya, 49(3), 250-262.
Nikiforova N.V. et al. Antioxidants in malignant human and experimental tumors // Biomeditsinskaya Khimiya. - 2003. - V. 49. -N 3. - P. 250-262.
Nikiforova N.V. et al., "Antioxidants in malignant human and experimental tumors." Biomeditsinskaya Khimiya 49.3 (2003): 250-262.
Nikiforova, N. V., Berman, A. E. (2003). Antioxidants in malignant human and experimental tumors. Biomeditsinskaya Khimiya, 49(3), 250-262.
Нейфах Е.А. (1978) Исследование системы витаминов Е и F в процессе злокачественного роста. Автореф. дис. канд. биол. наук.- Москва. Scholar google search
Okamoto К., Toyokuni S., Uchida К., Ogawa О., Takenewa J., Kakehi Y., Kinoshita H., Hattori- Nakakuki Y., Hiai H., Yoshida O. (1994) Int. J. Cancer, 58, 825- 829. Scholar google search
Langemann H., Torhorst J., Kabiersch A., Krenger W., Honegger C.G. (1989) Int. J. Cancer, 43, 1169- 1173. Scholar google search
Ahmed M.I., FayedS.Т., Hossein H., Tash E.M. (1999) Disease Markers, 15, 283- 291. Scholar google search
Dimitrov N.V., Pan R- Q., Bauer J., Jones T.I. (1994) Adv. Exp. Med. Biol., 364, 119- 127. Scholar google search
Gerber M., Astre C., Segala C., Saintot M., Scali J., Simoni- Lafontaine J., Grenier J., Pujol H. (1996) J. Nutr, 126, 1201S- 1207S. Scholar google search
Perry R.R., Mazetta J., Levin M., Barranco S.С. (1993) Cancer, 72, 783- 787. Scholar google search
Cook J.A., Pass H.I., Iype S.N., Friedman N., DeGraff W., Russo A., Mitchell J.B. (1991) Cancer Res., 51, 4287- 4294. Scholar google search
Porta С, Moroni M., Guallini P., Torri С, Marzatico F (1996) Anticancer Res., 16, 2741- 2748. Scholar google search
Klone A., Wiedner U., Hussnatter R., Harris J., Meyer D., Peter S., Ketterer В., Sies H. (1990) Carcinogenesis, 11, 2179- 2183. Scholar google search
Di Ilio C., Aceto A., Bucciarelli Т., Angelucci S., Felaco M., Grilli A., Zezza A., Tenaglia R., Federici G. ( 1991) Carcinogenesis, 12, 1471- 1475. Scholar google search
Grignon D.J., Abdel- Malak M., Mertens W.C., Sakr W.A., Shepherd R.R. (1994) Mol. Pathol., 7, 186- 189. Scholar google search
McCormick M.L., Oberley T.D., Elwel J.H., Oberley L.W., Sun Y., Li J.J. (1991) Carcinogenesis, 12, 977- 983. Scholar google search
Jaruga P., Zastcrwny Т.Н., Sfakowski J., Dizdaroglu M., Olinski R. (1994), FEBS Lett, 341, 59- 64. Scholar google search