At least two types of cell death are known: physiological (apoptosis) and pathological (necrosis). Dysregulation of apoptosis plays an important role in the pathogenesis of many pathological conditions. Their analysis gives a key for the development of novel therapeutic approaches. In this review the recent advances and perspectives for clinical use of apoptosis-modulating monoclonal antibodies, low-molecular-weight proteins, peptides, small non-peptide molecules and drugs targeting apoptosis-associated genes are summarized. The rationale for clinical application of apoptomodulators with the aim of increasing efficacy of existing standard therapies are also discussed.
Ruemmele F.M., Beaulieu J.E, O'Connell J., Bennett M. W., Seidman E.G., Lentze M.J. (2002) Biochem. Biophys. Res. Commun. 290, 1308- 1314 . Scholar google search
Conway E.M., Pollefeyt S., Steiner- Mosonyi M., Luo W., Devriese A., Lupu E., Bono E., Leducq N., Dol E., Schaeffer P., Collen D., Herbert J.M. (2002) Gastroenterology. 123, 619- 631 . Scholar google search
Rasper D., Vaillancourt J., Hadano S., Houtzager V.M., Seiden I., Keen S.L., Tawa P., Xanthoudakis S., Nasir J., Martindale D., Koop B.E, Peterson E.P., Thornberry N.A., Huang J., MacPherson D.P., Black S.C., Hornung E., Lenardo M.J., Hoyden M.R., Roy S., Nicholson D.W. (1998) Cell Death Differ. 5, 271- 288. Scholar google search
Jiang X.R., Jimenez G., Chang K., Frolkis M., Kusler В., Sage M., Beeche M., Bodnar A.G, Wahl G.M., Tlsty T.D., Chiu C.P. (1999) Nat. Genet. 21, 111- 114. Scholar google search
Morales С.Р., Holt S.E., Ouellette M., Kaur K.J., Yan Y., Wilson K.S., White M.A., Wright W.E., Shay J.W.(1999) Nat. Genet. 21,115- 118. Scholar google search
Schendel S.L., Montal M., Reed J.C. (1998) Cell Death Differ. 5, 372- 380. Scholar google search
Narita M., Shimizu S., Ito T., Chittenden T., Lutz R.J., Matsuda H., Tsujimoto Y. (1998) Proc. Natl. Acad. Sci. USA. 95, 14681- 14686. Scholar google search
Srinivasula S.M., Ahmad M., Fernandes- Alnemri T., Alnemri E.S. (1998) Mol. Cell. 1, 949- 957. Scholar google search
Shimizu S., Narita M., Tsujimoto Y. (1999) Nature. 399, 483- 487. Scholar google search
Ohmo S., Shimizu S., Ito T., Nomura M., Hamada E., Tsujimoto Y., Matsuda H. (1998) J. Biol. Chem. 273, 34272- 34277. Scholar google search
Morishima N., Nakanishi K., Takenouchi H., Shibata T., Yasuhiko Y. (2002) J. Biol. Chem. 277, 34287- 34294 . Scholar google search
Pan Z., Bhat M.B., Nieminen A.L., Ma J. (2001) J. Biol. Chem. 276, 32257- 32263. Scholar google search
Nutt L.K., Chandra J., Pataer A., Fang В., Roth J.A., Swisher S.G., O'Neil R.G., McConkey D.J. (2002) J. Biol. Chem. 277, 20301- 20308. Scholar google search
Mancini M., Machamer C.E., Roy S., Nicholson D.W., Thornberry N.A., Casciola- Rosen L.A., Rosen A. (2000) J. Cell Biol. 149, 603- 612. Scholar google search
Степанов Ю.М., Фильченков А.А., Кушлинский Н.Е. (2000) Система Fas/Fas- лиганд. Киев: ДИА. Scholar google search
Ichikawa K., Yoshida- Kato H., Ohtsuki M., Ohsumi J., Yamaguchi J., Takahashi S., Tani Y., Watanabe M., Shiraishi A., Nishioka K., Yonehara S., Serizawa N. (2000) Int. Immunol. 12, 555- 562. Scholar google search
Bozzo C., Bellomo G., Silengo L., Tarone G., Altruda F. (1997) Exp. Cell Res. 237,326- 337. Scholar google search
Rozzo C., Chiesa V., Caridi G., Pagnan G., Ponzoni M. (1997) Int. J. Cancer. 70,688- 698. Scholar google search
Gutheil J.C., Campbell Т.К. Pierce P.R., Watkins J.D., Huse W.D., Bodkin D.J. Cheresh D.A. (2000) Clin. Cancer Res. 6, 3056- 3061. Scholar google search
Nakajima A., Hirai H., Kayagaki N., Yoshino S., Hirose S., Yagita K., Okumura K. (2000) J. Autoimmun. 14, 151- 157. Scholar google search
Satoh K., Kikuchi S., Sekimata M., Kabuyama Y., Homma M.K., Homma Y. (2001) Arthritis Rheum. 44, 260- 265. Scholar google search
Walczak H., Miller R.E., Ariail K., Gliniak В., Griffith T.S., Kubin M., Chin W., Jones J., Woodward A., Le T., Smith C., Smolak R., Goodwin R.G., Rauch C.T., Schuh J.C., Lynch D.H. (1999) Nat. Med. 5, 157-163. Scholar google search
Bulfone- Paus S., Ruckert R., Krause H., von Bernuth K., Notter M., Pohl Т., Tran Т.Н., Paus R., Kunzendorf U. (2000) Transplantation. 69, 1386- 1391. Scholar google search
Seipelt G., Ottmann O.G., Hoelzer D. (2000) Curr. Opin. Hematol. 7, 156- 160. Scholar google search
Gruber H.E., Norton H.J., Hanley E.N., Jr. (2000) Spine. 25, 2153- 2157. Scholar google search
Rep M.H., Schrijver K.M., van Lopik T., Hintzen R.Q., Roos M.T., Ader H.J., Polman C.H., van Lier R.A. (1999) J. Neuroimmunol. 96, 92- 100. Scholar google search
Nguyen T., Thomas W., Zhang X.D., Gray C., Hersey P. (2000) Forum. 10, 243- 252. Scholar google search
Pandolfl F., Pierdominici M., Marziali M., Livia Bernardi M., Antonelli G., Galati V., D'Offizi G., Aiuti F. (2000) Clin. Immunol. 94, 153- 159. Scholar google search
Pietersen A., Noteborn K.M. (2000) Adv. Exp. Med. Biol. 465, 153- 161. Scholar google search
Danen- van Oorschot A.A., van Der Eb A.J., Noteborn M.H. (2000) J. Virol. 74, 7072- 7078. Scholar google search
Yepes M., Sandkvist M., Wong M.K., Coleman T.A., Smith E., Cohan S.L., Lawrence D.A. (2000) Blood. 96, 569- 576. Scholar google search
Park B.W., Zhang H.Т., Wu C., Berezov A., Zhang X., Dua R., Wang Q., Kao G., O'Rourke D.M., Greene M.L., Murali R. (2000) Nat. Biotechnol. 18, 194- 198. Scholar google search
Hadden H.L., Henke C.A. (2000) Am. J. Respir. Crit. Care Med. 162, 1553- 1560. Scholar google search
Chatterjee S., Matsumura A., Schradermeier J., Gillespie G.Y. (2000) J. Neurooncol. 46, 135- 144. Scholar google search
Giulian D., Haverkamp L.J., Yu J., Karshin W., Tom D., Li J., Kazanskaia A., Kirkpatrick J., Roher A.E. (1998) J. Biol. Chem. 273, 29719- 29726. Scholar google search
Wang J.L., Zhang Z.J., Chobi S., Shan S., Lu Z., Croce С.М., Alnemri E.S., Korngold R., Huang Z. (2000) Cancer Res. 60, 1498- 1502. Scholar google search
Brundin P., Karlsson J., Emgard M., Schierle G.S., Hansson O., Petersen A., Castilho R.F. (2000) Cell Transplant. 9, 179- 195. Scholar google search
Hansson O., Castilho R.F., Schierle G.S., Karlsson J., Nicotera P., Leist M., Brundin P. (2000) Exp. Neurol. 164, 102- 111. Scholar google search
Rabuffetti M., Sciorati C., Tarozzo G., Clementi E., Manfredi A.A., Beltramo M. (2000) J. Neurosci. 20, 4398- 4404. Scholar google search
Wang J.L., Liu D., Zhang Z.J., Shan S., Han X., Srinivasula S.M., Croce С.М., Alnemri E.S., Huang Z. (2000) Proc. Natl. Acad. Sci. USA, 97, 7124- 7129. Scholar google search
Lee D., Long S.A., Adams J.L., Chan G., Vaidya K.S., Francis T.A., Kikly K., Winkler J.D., Sung С.М., Debouch С., Richardson S., Levy M.A., DeWolf W.E., Jr, Keller P.M., Tomaszek Т., Head M.S., Ryan M.D., Haltiwanger R.C., Liang P.H., Janson C.A., McDevitt P.J., Johanson K., Concha N.O., Chan W., Abdel- Meguid S.S., Badger A.M., Lark M.W., Nadeau D.R, Suva L.J., Gowen M., Nuttall M.E. (2000) J. Biol. Chem. 275, 16007- 16014. Scholar google search
Ray S.K., Fidan M., Nowak M.W., Wilford G.G., Hogan E.L., Banik N.L. (2000) Brain Res. 852, 326- 334. Scholar google search
Rami A., Agarwal R., Botez G., Winckler J. (2000) Brain Res. 866, 299- 312. Scholar google search
Mackay K., Mochly- Rosen D. (1999) J. Biol. Chem. 274, 6272- 6279. Scholar google search
Zhu L., Yu X., Akatsuka Y., Cooper J.A., Anasetti С. (1999) Immunology. 97, 26- 35. Scholar google search
Harper S.J., Saporito M.S., Hewson L., Young L., Smith D., Rigby M., Jackson R., Curtis N., Swain C., Hefti E., Vaught J.L., Sirinathsinghji D. (2000) Neuroreport. 11, 2271- 2276. Scholar google search
Pirvola U., Xing- Qun L., Virkkala J., Saarma M., Murakata C., Camoratto A.M., Walton K.M., Ylikoski J. (2000) J. Neurosci. 20, 43- 50. Scholar google search
Alhasan S.A., Pietrasczkiwicz H., Alonso M.D., Ensley J., Sarkar F.H. (1999) Nutr. Cancer. 34, 12- 19. Scholar google search
Wu G., Tomei L.D., Bathurst I.С., Zhang E., Hong С.В., Issel C.J., Columbano A., Salley R.K., Chien S. (1997) Transplantation. 63, 803- 809. Scholar google search
Li Y., Chinni S.R., Senderowicz A.M., Sarkar F.H. (2000) Int. J. Oncol. 17, 755- 759. Scholar google search
Osuga H., Osuga S., Wang F., Fetni R., Hogan M.J., Slack R.S., Hakim A.M., Ikeda J.E., Park D.S. (2000) Proc. Natl. Acad. Sci. USA. 97, 10254- 10259. Scholar google search
Perry P.J., Gowan S.M., Reszka A.P., Polucci P., Jenkins T.C., Kelland L.R., Neidle S. (1998) J. Med. Chem. 41, 3253- 3260. Scholar google search
Hsu A.L., Ching T.T., Wang D.S., Song X., Rangnekar V.M., Chen C.S. (2000) J. Biol. Chem. 275, 11397- 11403. Scholar google search
Kobayashi Т., Okamoto K., Kobata Т., Hasunuma Т., Kato Т., Hamada H., Nishioka К. (2000) Gene Ther. 7, 527- 533. Scholar google search
Ohashi M., Kanai F., Ueno H., Tanaka Т., Tateishi K., Kawakami Т., Koike Y., Ikenoue Т., Shiratori Y., Hamada H., Omata M. (1999) Gut. 44, 366- 371. Scholar google search
Hwang R.F., Gordon E.M., Anderson. W.F., Parekh D. (1998) Surgery. 124, 143- 150. Scholar google search
Zou Y., Zong G., Ling Y.H., Hao MM., Lozano G., Hong W.K., Perez- Soler R. (1998) J. Natl. Cancer Inst. 90, 1130- 1137. Scholar google search
Roth J.A., Nguyen D., Lawrence D.D., Kemp B.L., Carrasco C.H., Ferson D.Z., Hong W.K., Komaki R., Lee J.J., Nesbitt J.C., Pisters K.M., Putnam J.B., Schea R., Shin D.M., Walsh G.L., Dolormtnte M.M., Han C.I., Martin F.D., Yen N., Xu K., Stephens L.C., McDonnell T.J., Mukhopadhyay Т., Cai D. (1996) Nat. Med. 2,985- 991. Scholar google search
Zou Y., Zong G., Ling Y.H., Perez- Soler R. (2000) Cancer Gene Ther. 7, 683- 696. Scholar google search
Rudolph K.L., Chang S., Millard M., Schreiber- Agus N., DePinho R.A. (2000) Science. 287, 1253- 1258. Scholar google search
McKinnon S.J., Lehman D.M., Tahzib N.G., Ransom N.L., Reitsamer H.A., Liston P., LaCasse K., Li Q., Korneluk R.G., Hauswirth W.W. (2002) Mol. Ther. 5, 780- 787. Scholar google search
Rabinovitch A., Suarez- Pinzon W., Strynadka K., Ju Q., Edelstein D., Brownlee M., Korbutt G.S., Rajotte R.V. (1999) Diabetes. 48, 1223- 1229. Scholar google search
Contreras J.L., Bilbao G., Smyth C.A., Eckhoff D.E., Jiang X.L., Jenkins S., Thomas F.T., Curiel D.T., Thomas J.M. (2002) Kidney Int. 61 (Suppl. 1), 79- 84. Scholar google search
Swenson K.M., Ke В., Wang Т., Markowitz J.S., Maggard M.A., Spear G.S., Imagawa D.K., Goss J.A., Busuttil R.W., Seu P. (1998) Transplantation. 65, 155- 160. Scholar google search
Phelan A., Elliott G., O'Hare P. (1998) Nat. Biotechnol. 16, 440- 443. Scholar google search
Wybranietz W.A., Prinz F., Spiegel M., Schenk A., Bitzer M., Gregor M., Lauer U.M. (1999) J. Gene Med. 1, 265- 274. Scholar google search
Shand N., Weber F., Mariani L., Bernstein M., Gianella- Borradori A., Long Z., Sorensen A.G., Barbier N. (1999) Hum. Gene Ther. 10, 2325- 2335. Scholar google search
Herman J.R., Adler H.L., Aguilar- Cordova E., Rojas- Martinez A., Woo S., Timme T.L., Wheeler T.M., Thompson T.C., Scardino P.T. (1999) Hum. Gene Ther. 10, 1239- 1249. Scholar google search
Raez L., Cabral L., Cai J.P., Landy H., Sfakianakis G., Byrne G.E., Jr, Hurley J., Scerpella E., Jayaweera D., Harrington W.J., Jr. (1999) AIDS Res. Hum. Retro- viruses. 15, 713- 719. Scholar google search
Klebba C., Ottmann O.G., Scherr M., Pape M., Engels J.W., Grez M., Hoelzer D., Klein S.A. (2000) Gene Ther. 7, 408- 416. Scholar google search
Villanova I., Townsend P.A., Uhlmann E., Knolle J., Peyman A., Amling M., Baron R., Horton M.A., Teti A. (1999) J. Bone Miner. Res. 14, 1867- 1879. Scholar google search
Suzuki J., Isobe M., Morishita R., Nishikawa Т., Amano J., Kaneda Y. (2000) Cardiovasc Res. 45, 783- 787. Scholar google search
Julien T., Frankel В., Longo S., Kyle M., Gibson S., Shillitoe E., Ryken T. (2000) Surg. Neurol. 53, 360- 368. Scholar google search
Ziegler A., Luedke G.H., Fabbro D., Altmann К.Н., Stahel R.A., Zangemeister- Wittke U. (1997) J. Natl. Cancer Inst. 89, 1027- 1036. Scholar google search
Konopleva M., Tari A.M., Estrov Z., Harris D., Xie Z., Zhao S., Lopez- Berestein G., Andreeff M. (2000) Blood. 95, 3929- 3938. Scholar google search
Waters J.S., Webb A., Cunningham D., Clarke P.A., Raynaud F., di Stefano F., Cotter F.E. (2000) J. Clin. Oncol. 18, 1812- 1823. Scholar google search
Morris M., Tong W., Osman I. (1999) Proc. Am. Soc. Clin. Oncol. 18, 323a. Scholar google search
Schlagbauer- Wadl H., Klosner G., Heere- Ress E., Waltering S., Moll I., Wolff К., Pehamberger К., Jansen В. (2000) J. Invest. Dermatol. 114, 725- 730. Scholar google search
Kampmeier J., Behrens A., Wang Y., Yee A., Anderson W.E., Hall E.L., Gordon E.M., McDonnell P.J. (2000) Hum. Gene Ther. 11, 1- 8. Scholar google search
Min W.E., Gorczynski R., Huang X.Y., Kushida M., Kim P., Obataki M., Lei J.,SuriR.M., Cattral M.S. (2000) J. Immunol. 164, 161- 167. Scholar google search
Milas L., Mason K., Hunter N., Petersen S., Yamakawa M., Ang K., Mendelsohn J., Fan Z. (2000) Clin. Cancer Res. 6, 701- 708. Scholar google search
Slamon D., Leyland- Jones В., Shak S. (1998) Proc. Am. Soc. Clin. Oncol. 17, 98a. Scholar google search
Winer E.P., Burstein H.J., Kuter I. (1999) Abstr. San Antonio Breast Cancer Symp. San Antonio, Dec 8- 11, 1999. Scholar google search
Teicher B.A., Alvarez E., Mendelsohn L.G., Ara G., Menon K., Ways D.K. (1999) Adv. Enzyme Regul. 39, 313- 327. Scholar google search
Fabbro D., Ruetz S., Bodis S., Pruschy M., Csermak K., Man A., Campochiaro P., Wood J., O'Reilly Т., Meyer T. (2000) Anticancer Drug Des. 15, 17- 28. Scholar google search
