Myelin oligodendrogliocyte glycoprotein the structure, functions, role in pathogenesis of demyelinating diseases

   
Chekhonin V.P.1, Semenova A.V.1, Gurina O.I.1, Dmitrieva T.B.1

1. Serbsky National Research Centre For Social and Forensic Psychiatry
Section: Review
PubMed Id: 16119093
Year: 2003  Volume: 49  Issue: 5  Pages: 411-423
Myelin oligodendrocyte glycoprotein (MOG) is a myelin-specific protein of the central nervous system (CNS). It is a member of the immunoglobulin superfamily. The contents of this protein in oligodendrogliocyte membrane is very low (approximately 0.1% total proteins). functions of MOG are still unknown. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. The structure, membrane topology, putative functions and role in demyelinating diseases are considered in this review.
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Chekhonin, V. P., Semenova, A. V., Gurina, O. I., Dmitrieva, T. B. (2003). Myelin oligodendrogliocyte glycoprotein the structure, functions, role in pathogenesis of demyelinating diseases. Biomeditsinskaya khimiya, 49(5), 411-423.
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