Purification and characteristic of the protein c activator from Agkistrodon halys halys snake venom

   
Gornitskaya O.V.1 , Platonova T.N.1

1. Palladin Institute of Biochemistry, National Academy of Sciences
Section: Experimental/Clinical Study
PubMed Id: 16119100
Year: 2003  Volume: 49  Issue: 5  Pages: 470-478
Protein C activator from Agkistrodon halys halys venom has been purified by ion-exchange and gel-filtration chromatography. The purified enzyme consists of a single peptide chain with molecular weight of 34 kD. Its pH-optimum was the range of 7,5-8,0. The enzyme was inhibited by DFP, benzamidine, PMSF, EGTA. Protein C activator was as effective as Protac (Pentapharm AG, Switzerland) for determination of protein C level in blood plasma using APTT test and protein C chromogenic substrate.
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Gornitskaya, O. V., Platonova, T. N. (2003). Purification and characteristic of the protein c activator from Agkistrodon halys halys snake venom. Biomeditsinskaya khimiya, 49(5), 470-478.
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