Starting mechanisms of trypsinogen activation and the role of trypsin in pathogenesis of acute pancreatitis

   
Shabanov V.V.1

1. Samara Military Medical Institute
Section: Miscellaneous
PubMed Id: 16119103
Year: 2003  Volume: 49  Issue: 5  Pages: 491-501
Early events critical for the development acute pancreatitis are considered. The possible initiating mechanisms of intracellular trypsinogen activation are discussed. Essential attention is paid to the role of cathepsin B, intraacinar [Ca2+] increase and free radicals generation in the premature zimogen activation. It is demonstrated, that the trypsinogen activation alone may not be sufficient to cause acinar cell injury. Some factors, other than active trypsin, play a main role in the pancreatic damage and in the development of systemic complications of acute pancreatitis.
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Shabanov V.V. (2003) Biomeditsinskaya khimiya, 49(5), 491-501.
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