Effects of metformin on endocrine parameters and reproductive system in women with polycystic ovary syndrome

   
Valueva L.G.1 , Chernukha G.E.2, Ametov A.S.1

1. Department Endocrinology and Diabetology of the RMAPE
2. Research Center for Obstetrics, Gynecology and Perinatology of the RAMS
Section: Experimental/Clinical Study
PubMed Id: 16119083
Year: 2003  Volume: 49  Issue: 6  Pages: 548-553
The effect of metformin has been studied among 42 patients of reproductive age with polycystic ovary syndrome. Therapy for 6-months was associated with regular menstrual cycle in 54,3% women, (ovulation was observed in 28,6%). After therapy 19,1% patients became pregnant. Serum levels LH fell from 16.3±1.45 to 8.9±0.82 IU/l, T from 3.3±0.17 to 2.0±0.17 nmol/l, (p<0.01). We noted increase of GH from 2,7±0,98 to 9,0±1,91nmol/l and SHBG from 36,4± 2,6 to 58,2±4,11 nmol/l, (p<0.01). After therapy we observed decrease of insulin responses during oral glucose tolerance test, (p<0.05).
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Valueva L.G., Chernukha G.E., Ametov A.S. (2003) Biomeditsinskaya khimiya, 49(6), 548-553.
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