Forced alcoholization of rats according to Majchrowicz led to the development of fatty liver. The subsequent ethanol withdrawal was accompanied by amino acid imbalance in the pool of free sulfur-containing and glycogenic amino acids in liver and blood plasma. Similar changes were observed after prolonged alcohol intoxication. Intragastric administration of the amino acid composition containing branched-chain amino acids and taurine corrected the amino acid imbalance and reduced the development of the steatosis of the liver.
Razvodovsky Yu.Ye. et al. Hepatoprotective effects of branched chain амinо acids and taurine rats undergoing subchronic alcohol intoxication and withdrawal // Biomeditsinskaya Khimiya. - 2004. - V. 50. -N 1. - P. 64-72.
Razvodovsky Yu.Ye. et al., "Hepatoprotective effects of branched chain амinо acids and taurine rats undergoing subchronic alcohol intoxication and withdrawal." Biomeditsinskaya Khimiya 50.1 (2004): 64-72.
Razvodovsky, Yu. Ye., Doroshenko, Ye. M., Prokopchik, N. I., Smirnov, V. Yu., Ostrovsky, S. Yu. (2004). Hepatoprotective effects of branched chain амinо acids and taurine rats undergoing subchronic alcohol intoxication and withdrawal. Biomeditsinskaya Khimiya, 50(1), 64-72.
Liber С. S. (1985) In: Acta Medica Scandinavica symposium Series No.l Stockholm: Almquist and Wilksell International, pp. 11- 56. Scholar google search
Nanji Amin A., Tsukamoto Hidekazu, French Samuel W. (1989) Exp. Mol. Pathol., 51, 141- 148. Scholar google search
Yuki Т., Yoshitoko K., Nakagawa Y. (1988) Med. Biochem. and Chem. Aspects Free Radicals: Proc. 4 th Gen. Meet. Soc. Free Radical Res., Kyoto, 2. pp. 967- 970. Scholar google search
Kerai M.D., Waterfield C.J., Kenyon S.H., Asker D.S., Tirmbell J.A. (1999) Alcohol and Alcoholism. №4, 529- 541. Scholar google search
Majchrowicz E., Hunt W.A. (1980) Animal Models in Alcohol Research (Eriksson K., Sinclair J.D., Kiianmaa K., eds.). Acad.Press., N.Y, pp. 419- 424. Scholar google search
