Hepatoprotective effects of branched chain амinо acids and taurine rats undergoing subchronic alcohol intoxication and withdrawal

   
Razvodovsky Yu.Ye.1, Doroshenko Ye.M.2, Prokopchik N.I.1, Smirnov V.Yu.2, Ostrovsky S.Yu.2

1. Institute of Biochemistry, national Academy of Sciences, Grodno, Belarus
2. State Medical University
Section: Experimental/Clinical Study
PubMed Id: 15108628
Year: 2004  Volume: 50  Issue: 1  Pages: 64-72
Forced alcoholization of rats according to Majchrowicz led to the development of fatty liver. The subsequent ethanol withdrawal was accompanied by amino acid imbalance in the pool of free sulfur-containing and glycogenic amino acids in liver and blood plasma. Similar changes were observed after prolonged alcohol intoxication. Intragastric administration of the amino acid composition containing branched-chain amino acids and taurine corrected the amino acid imbalance and reduced the development of the steatosis of the liver.
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Razvodovsky, Yu. Ye., Doroshenko, Ye. M., Prokopchik, N. I., Smirnov, V. Yu., Ostrovsky, S. Yu. (2004). Hepatoprotective effects of branched chain амinо acids and taurine rats undergoing subchronic alcohol intoxication and withdrawal. Biomeditsinskaya khimiya, 50(1), 64-72.
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