1. Institute of cytology and genetics, Siberian branch of Russian academy of sciences, Institute of physiology, siberian branch of Russian academy of medical sciences 2. Institute of molecular biology and biophysics, Siberian branch of Russian academy of medical sciences 3. Institute of cytology and genetics, Siberian branch of Russian academy of sciences
Age-dependent variations in products of lipid peroxidation products (LPO) and oxidative damage of proteins have been studied in the liver mitochondria and microsomes of premature aging OXYS rats. Characteristics of oxidative processes in OXYS rats were compared with parameters in Wistar rats. Changes in lipid peroxidation products content and oxidative damage of proteins in rat liver mitochondria and microsomes of both strains rats were nonlinear and had opposite direction during the first year of life. The level of protein oxidative damage in OXYS rat liver mitochondria and cytosol was higher than in Wistar at 12 months. The content of primary and end lipid peroxidation products in OXYS rat liver microsomes was significantly decreased in 12 months, but content of conjugated dienes was increased in mitochondria.