The long-term influnce of arochlor 1254 on microsomal monooxygenase system of rat liver at acute pancreatitis

   
Prokopieva N.V.1, Gulyaeva L.F.1, Polyakova N.E.1

1. Institute of Molecular Biology and Biophysics, Siberian Branch, Russian Academy of Medical Science
Section: Experimental/Clinical Study
PubMed Id: 15179822
Year: 2004  Volume: 50  Issue: 2  Pages: 159-163
Constitutive activities of the liver cytochromes P450 1A1, 1A2, 2C6 and 2B1 were lower in rats with the acute experimental pancreatitis during ten days of this disease. In rats pretreated with a single dose of Arochlor 1254 on the second day of pancreatitis activities of these enzymes remained elevated to the tenth day. Thus, acute pancreatitis caused long-term suppression of microsomal monooxygenase system, whereas induction by Arochlor 1254 increased cytochromes P450 activity in both control animals and in rats with pancreatitis.
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Prokopieva, N. V., Gulyaeva, L. F., Polyakova, N. E. (2004). The long-term influnce of arochlor 1254 on microsomal monooxygenase system of rat liver at acute pancreatitis. Biomeditsinskaya khimiya, 50(2), 159-163.
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