Cysteine proteinases and their inhibitors in murine HA-1 hepatoma during antitumor treatment

Poteryaeva O.N.1, Korolenko T.A.1, Svechnikova I.G.1, Zhanaeva S.Ya.1, Falameyeva O.V.1, Kaledin V.I.2, Nowicky J.V.3

1. Institute of Physiology RAMS, Institute of Biochemistry RAMS
2. Institute of Cytology and Genetics RAS, Novosibirsk
3. NowickyPharma, Austria
Section: Experimental/Clinical Study
PubMed Id: 15179824
Year: 2004  Volume: 50  Issue: 2  Pages: 172-179
Development of murine HA-1 hepatoma was accompanied by increased activity cathepsin B (in ascitic cells), cathepsin D (in ascitic fluid) and increased activity of procathepsin B. There were some changes of cysteine proteinases in liver and spleen, not involved directly into tumor growth. The most prominent changes included the decreased level of cysteine proteinase inhibitors сystatin C and stefin A in ascitic cells (and to a lesser degree in liver tissue). During tumor development serum cystatin C concentration was decreased 3-times compared to intact mice. Treatment by antitumor drug Ukrain increased life span of mice with HA-1 hepatoma (transplanted intravenously), decreased the increment of tumor gain; in ascite the number of tumor cells decreased and number of macrophages increased. Ukrain (administered once or 5-times in a dose of 0.5 mg per mice) increased cystatin C level, revealing protective mechanism of action.
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Poteryaeva, O. N., Korolenko, T. A., Svechnikova, I. G., Zhanaeva, S. Ya., Falameyeva, O. V., Kaledin, V. I., Nowicky, J. V. (2004). Cysteine proteinases and their inhibitors in murine HA-1 hepatoma during antitumor treatment. Biomeditsinskaya Khimiya, 50(2), 172-179.
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