The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain under altitude chamber treatment (6000 m x 24 hours) were investigated. Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test. Administration of LiCl caused reduction of phosphoinositide level; hypoxia (6000 m) causedfurther impairments in the second messenger content. There was synergism of interaction between between phosphoinositide and adenylatcyclase systems were demonstrated.
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Vishnevsky A.A., Jakovlev V.M., Habibullova Z.I. (2004) The second messendger response under altitude chamber treatment. Biomeditsinskaya Khimiya, 50(2), 187-191.
Vishnevsky A.A. et al. The second messendger response under altitude chamber treatment // Biomeditsinskaya Khimiya. - 2004. - V. 50. -N 2. - P. 187-191.
Vishnevsky A.A. et al., "The second messendger response under altitude chamber treatment." Biomeditsinskaya Khimiya 50.2 (2004): 187-191.
Vishnevsky, A. A., Jakovlev, V. M., Habibullova, Z. I. (2004). The second messendger response under altitude chamber treatment. Biomeditsinskaya Khimiya, 50(2), 187-191.
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