Dose-dependent effects of morphine hydrochloride on the functioning of glycolysis in the rat liver

   
Lelevich S.V.1

1. Grodno State Medical University
Section: Experimental/Clinical Study
PubMed Id: 15354538
Year: 2004  Volume: 50  Issue: 3  Pages: 273-276
The effect of acute morphine intoxication (10, 20 and 40 mg/kg body weight) on the functioning of glycolysis in the rat liver was studied. The most pronounced effect was noted at the dose of 10 mg/kg. it included activation of key glycolytic enzymes: hexokinase, glucokinase and phosphofructokinase and increase blood and liver tissue glucose being increased. The elevated morphine dose did not change glycolytic enzyme activities, decreasing glucose and glucose-6-phosphate contents.
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Lelevich, S. V. (2004). Dose-dependent effects of morphine hydrochloride on the functioning of glycolysis in the rat liver. Biomeditsinskaya khimiya, 50(3), 273-276.
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