Soyabean phospholipids, particularly commercial lecithin, are now widely used as biological active food additives. Mechanisms of their activities are based mainly on their similarity with own phospholipids of biomembranes and blood lipoproteins. The similarity allows the inclusion of plant phospholipids into these structures and promotes prevention of number of pathological processes. Soybean phospholipids have a wide range of biochemical and physical effects. Lecithin complex is the source of easily accessible linoleic acid, choline and inositol. Lecithin plays a notable role as synergist for antioxidants also. The proven health benefits which can be achieved by taking soybean phospholipids include lipid-lowering; control of blood levels of cholesterol and triglyceride, stabilisation of the membrane functions, supporting the hepatic functions. Structure, some physico-chemical properties and metabolism of phospholipids, and molecular mechanisms of their prophylactic effects are briefly reviewed.
Download PDF:
Citation:
Ipatova O.M., Prosorovskaya N.N., Torhovskaya T.I., Baranova V.S., Guseva D.A. (2004) Biological effects of the soybean phospholipids. Biomeditsinskaya Khimiya, 50(5), 436-450.
Ipatova O.M. et al. Biological effects of the soybean phospholipids // Biomeditsinskaya Khimiya. - 2004. - V. 50. -N 5. - P. 436-450.
Ipatova O.M. et al., "Biological effects of the soybean phospholipids." Biomeditsinskaya Khimiya 50.5 (2004): 436-450.
Ipatova, O. M., Prosorovskaya, N. N., Torhovskaya, T. I., Baranova, V. S., Guseva, D. A. (2004). Biological effects of the soybean phospholipids. Biomeditsinskaya Khimiya, 50(5), 436-450.
Carrie I., Clement M, de Javel D., Frances K, Bourre J.- M. (2000) J. Lipid Res., 41, 465- 472. Scholar google search
Clore J.N., Li J., Gill R., Gupta S., Spencer R., Azzam A., Zuelzer W., Rizzo W.B., Blackard W.G. (1998) Am. J. Physiol. Endocrinol Metab., 275, ' • - E665- E670. Scholar google search
Nordskog B.K., Phan С.Т., Nutting D.К, Tso P. (2001) Advanced Drug Delivery Reviews., 50, 21- 44. Scholar google search
Le Kim D., Betzing H. (1976) Hoppe- Seylers Z. Physiol. Chem., 357, 1321- 1331. Scholar google search
Fox J.M., Betzing K., Lekim D. (1979) In Nutrition and Brain (Ed. Barleau A., Growdon J.M., Wurtman J.R.), Raven Press, New York, 5, pp. 95- 108. Scholar google search
Zeirenberg O., Grundy S.M. (1982) J. Lipid Res., 23, 1136- 1141. Scholar google search
Arnesjo В., Nilsson A., Barrowman J., Borgstrom B. (1969) Scand. J. Gastroenterol., 4, 653- 665. Scholar google search
Borgstrom В., Dahlqvist A., Lundh G., Sjovall J. (1957) J. Clin. Invest., 36, 1521- 1536. Scholar google search
Zeisel S.H. (1988) in: Modern Nutrition in Health and Disease (M.E. Shils and V.R.Young eds.) Lea and Febiger, Philadelphia, pp. 440- 458. Scholar google search
Гриффит В. (2000) Витамины, травы, минералы и пищевые добавки. Справочник. Пер. с англ. М , ФАИР- ПРЕСС, с. 1007- 1010. Scholar google search
Ladd S.L., Sommer S.A., LaBerge S., Toscano W. (1990) Clinical Neuropharmacology, 16, 540- 549. Scholar google search
Little A., Levy P., Chuaqui- Kidd, Hand D. (1985) J. Neurol. Neurosurg. Psychiatry, 48, 736- 742. Scholar google search
Nitsch R.M., Blusztajn J.K., Pittas A.G., Slack B.E., Growdon J.H, Wurtman R.J. (1992) Proc. Natl. Acad. Sci. USA, 89, 1671- 1675. Scholar google search
Holford N.H.G., Peace K. (1994) Eur. J. Clin. Pharmacol., 47, 17- 23. Scholar google search
Farooqui A.A., Horrocb L.A., Farooqui T. (2000) Chem. Phys. Lipids, 106, 1- 29. Scholar google search
Pruzanski W., Stefanski E., de Reer E.G., de Beer M.C., Vadas P., Ravandi A., Kuksis A. (1998) J. Lipid Res., 39, 2510- 2560. Scholar google search
Gundermann K.- J. (1993) The "Essential" Phospholipids as a Membrane Therapeutic (K.- J. Gundermann ed.). Publisher: Polish Section of European Society of Biochemical Pharmacology. Szczecin. Scholar google search
Juzwiak S., Wojcicki J., Machoy- Mokrzynska A., Samochowiec L., Biaecka M. (1996) Phytomedicine, 2, 199- 204. Scholar google search
Nikitina N., Torkhovskaya Т., Markin S. et al. (1994) Joint XII World Congr. Cardiol., Berlin 1994, abstr. 2559. Scholar google search
Wojcicki J., Pawlik A., Samochowiec L., Kaldonska M., Mysliwiec Z. (1995) Phytother. Res., 9, 597- 599. Scholar google search
Berliner J.A., Heinecke J.W. (1996) Free Rad. Biol. Med., 20, 707- 727. Scholar google search
Croft K.D., Williams P., Dimmitt S., Abu- Amsha R., Beilin L.J. (1995) Biochim. Biophys. Acta, 1254, 250- 256. Scholar google search
Ланкин В.З. (1997) Биоантиоксидант, Материалы международного симпозиума в рамках международной выставки "Медицина и охрана здоровья. Медтехника и Аптека" (16- 19 сентября). Тюмень, с. 51- 53. Scholar google search
Fyrnys В., Blencowe Ch, Deigner H.- P. (1995) FEBS Lett., 357, 7- 12. Scholar google search
Berliner J.A., Territo M.C., Sevanian A., Ramin S., KimJ.A., Bamshad В., Esterson M., Fogelman A.M. (1990) J. Clin. Invest., 85, 1260- 1266. Scholar google search
Berlinger J.A., Gerrity R.G. (1992) in: Molecular Genetics of Coronary Artery Disease. (A.J. Lusis, J- Д. Routter and R.S. Sparkes eds.) S. Karger, Basel, Switzerland, pp. 1- 15. Scholar google search
Subbanagounder G., Leitinger N., Schwenke D.C., Wong J.W., Lee H., et al. (2000) Arterioscler. Thromb. Vase. Biol., 20, 2248- 2254. Scholar google search
Zeisel S.H. (1989) in : Lecithin: sources, manufacture, and uses. (B.F. Szuhai ed.) Champaign, IL: American Oil Chemical Society, pp. 225- 236. Scholar google search
Lieber C.S., DeCarli L.M., Мак К.М., Kim C.L, Leo M.A. (1990) Hepatology, 12, 1390- 1398. Scholar google search
Lieber C.S., Leo M.A., Мак K.M., DeCarli L.M., Sato S. (1985) Hepatology, 5,561- 572. Scholar google search
Lieber C.S., Robins S.J., Li J. DeCarli L.M., Mak K.M., Fasulo J.M., Leo M.A. (1994) Gastroenterology, 106, 152- 159. Scholar google search
Подобед О.В., Федорова Л.М., Якушева К.В., Абакумова О.Ю., Корякин А.В., Гаврильчак А.В., Шехтер А.Б. (1995) в кн. "Новые технологии в хирургической гепатологии" Материалы третьей конференции хирургов- гепатологов. 14- 16 июня 1995 г.. г. Санкт- Петербург, с. 427- 428. Scholar google search
Ипатова О.М., Арчаков А.И., Учайкин В.Ф., Торховская Т.Н. (2001) Российский гастроэнтерологический журнал, 2, 127- 128. Scholar google search
Сторожок Н.М. (1996) Межмолекулярные взаимодействия компонентов природных липидов в процессе окисления. Автореф. дисс. докт. наук, Институт химической физики РАН, Москва. Scholar google search
Orrenius S., McConkey D.J., Nicotera P. (1988) in Oxy- radicals in Molecular Biology and Pathology. Alan R. Liss, Inc.^New York, NY, pp. 327- 339. Scholar google search
Hochgraf E., Mocady Sh., Cogan U. (1997) J. Nutr., 127, 681- 686. Scholar google search
Witztum J.L., Steinberg D. (1991) J. Clin. Invest., 88, 1785- 1792. Scholar google search
Drown B.G., Cheung M.C., Lee A.C., Zhao X.- Q., Chait A. (2002) Arterioscler., Thromb., Vase. Biol., 22, 1535- 1541. Scholar google search
Rice- Evans C.A., Miller N.J., Paganga G. (1996) Free Rad. Biol. Med., 20, 933- 956. Scholar google search
Packer L., Rimbach G., Virgili F. (1999) Free Radi. Biol. Med., 27. 704- 724. Scholar google search
Morton L.W., Caccetta R., Puddey I.B., Croft K.D. (2000) Clin. Exp. Pharmacol. Physiol., 27, 152- 159. Scholar google search
Прозоровская Н.Н., Русина И.Ф., Прозоровский В.Н., Ипатова О.М. (2002) Биоантиоксидант, VI Международная конференция, Москва, 16- 19 апреля 2002 года. Тезисы докладов, с. 474- 475. Scholar google search
Ипатова О.М., Прозоровская К.Н., Русина И.Ф., Прозоровский В.Н. (2003) Биомед. химия №2, 165- 176. Scholar google search
Ипатова О.М., Русина И.Ф., Прозоровский В.К., Прозоровская Н.Н. (2003) в кн.: Актуальные проблемы инноваций с нетрадиционными природными ресурсами и создания функциональных продуктов: Материалы II Российской научно- практической конференции. - М.: РАЕН- МААНОЙ. с. 202- 203. Scholar google search
Marriot B.M. (ed.) (1994) in Conclusions and recommendations. National Academy Press, Washington, D.C., pp. 47- 61. Scholar google search
