Alimentary induced oxidative stress and its corrections in children and adults with homocysteine metabolism disorder are urgent problems for arteriosclerosis and cardiovascular disease prophylactics. For determination antioxidant status GSH-Px, SOD, GSH-reductase, catalase activities were detected. Effectiveness of Se-contained antioxidant complex "Selenec" was determined in experimental model with pubertal male Wistar rats. Including high value of methionine to semipurified diet with pyridoxine and folate deficiency induced oxidative stress. Lipid peroxidation substances were increased in blood, liver, intestine mucous tunic, aortal endothelium and myocardium. GSH-Px, SOD, GSH-reductase, catalase activities decreased significant compared to control. "Selenec" supplementation caused a decrease of thiobarbituric-reactive substances level, increasing SOD and catalase activity and decreasing GSH-Px and GSH-reductase activity in blood, liver, intestine mucous tunic, aorta and myocardium.
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Kravchenko J.V., Maltzev G.J., Vasiliev A.V. (2004) Research of antuioxidant defence system under alimentary induced oxidative stress. Biomeditsinskaya Khimiya, 50(5), 477-483.
Kravchenko J.V. et al. Research of antuioxidant defence system under alimentary induced oxidative stress // Biomeditsinskaya Khimiya. - 2004. - V. 50. -N 5. - P. 477-483.
Kravchenko J.V. et al., "Research of antuioxidant defence system under alimentary induced oxidative stress." Biomeditsinskaya Khimiya 50.5 (2004): 477-483.
Kravchenko, J. V., Maltzev, G. J., Vasiliev, A. V. (2004). Research of antuioxidant defence system under alimentary induced oxidative stress. Biomeditsinskaya Khimiya, 50(5), 477-483.
Jacobsen D., Troxell L., Brown K. (1984) Biochemistry, 23, 2017- 2025. Scholar google search
Sengupta S., Chen H, Togawa Т., DiBello P., Majors A., Bucfy В., Ketterer M., Jacobsen D. (2001) J.Biol.Chem., 276, 30111- 30117. Scholar google search
Chambers J., McGregor A., Jean- Marie J., Obeid O., Kooner J. (1999) Circulation., 99, 1156- 1160. Scholar google search
Nappo E., De Rosa N., Marfella R., De Lucia D., Ingrosso D., Perna A., Farzati В., Giuglano D. (1999) JAMA, 281, 2113- 2118. Scholar google search
Боряев Г.И. (2000) Биохимический и иммунологический статус молодняка с/х животных и птицы и его коррекция препаратами селена. Автореф. дисс. д.б.н, Москва. Scholar google search
Мальцев Г.Ю., Васильев А.В. (1994) Вопр. мед. химии, № 2, 56- 58. Scholar google search
Lang D., Kredan M., Moat S., Hussain S., Powell C., Bellamy M., Powers H., Lewis M. (2000) Arterioscl. Thromb. Vasc.Biol., 20, 422- 431. Scholar google search
Huang R., Hsu Y., Lin H., Yang F. (2001) J. Nutrition., 131, 33- 38. Scholar google search
Jacubovski H., Zhang L., Bardegues A., Aviv A. (2000) Circ.Res., 87, 45- 56. Scholar google search
Davies M., Fu S., Wang H., Dean R. (1999) Free.Radic.Biol.Med., 27, 1151- 1163. Scholar google search
Боряев Г.И., Галочкин В.А., Блинохватов А.Ф. (1990) Бюлл.ВНИИФБиП с.- х. животных, 3, 70- 73. Scholar google search
Welch G., Upchurch G., Keaney J., Loscalzo J. (1996) J. Am. Coll. Cardiol., 27 164- 171. Scholar google search
Frei В., Stocker R., England L., Ames B. (1990) Adv. Exp. Med. Biol., 264, 155- 163. Scholar google search
Outinen P., Sood S., Pfeifer S., Pamidi S., Podor Т., Li J., Weitz J., Austin R. (1999) Blood, 94, 959- 967. Scholar google search
Weiss N., Zhang Y., Heydrick S., Bierl C., Loscalzo J. (2001) Proc. Natl. Acad. Sci. USA. 98, 12503- 12508. Scholar google search
Huang R., Hsu Y., Lin H., Yang F. (2001) J.Nutr., 131, 33- 38 " ". Scholar google search
