Research of antuioxidant defence system under alimentary induced oxidative stress

Kravchenko J.V.1, Maltzev G.J.1, Vasiliev A.V.1

1. Institute of Nutrition Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
PubMed Id: 15628597
Year: 2004  Volume: 50  Issue: 5  Pages: 477-483
Alimentary induced oxidative stress and its corrections in children and adults with homocysteine metabolism disorder are urgent problems for arteriosclerosis and cardiovascular disease prophylactics. For determination antioxidant status GSH-Px, SOD, GSH-reductase, catalase activities were detected. Effectiveness of Se-contained antioxidant complex "Selenec" was determined in experimental model with pubertal male Wistar rats. Including high value of methionine to semipurified diet with pyridoxine and folate deficiency induced oxidative stress. Lipid peroxidation substances were increased in blood, liver, intestine mucous tunic, aortal endothelium and myocardium. GSH-Px, SOD, GSH-reductase, catalase activities decreased significant compared to control. "Selenec" supplementation caused a decrease of thiobarbituric-reactive substances level, increasing SOD and catalase activity and decreasing GSH-Px and GSH-reductase activity in blood, liver, intestine mucous tunic, aorta and myocardium.
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Kravchenko J.V., Maltzev G.J., Vasiliev A.V. (2004) Biomeditsinskaya khimiya, 50(5), 477-483.
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