Administration of toxic doses of means specific tuberculostatics chemotherapy to rats caused development of medicinal damages of liver, kidneys, and pancreas. Use of 2-ethyl-6-methyl-hydroxypyridine succinate (SEMOP) and S-adenosyl-L-methionine reduced manifestations of pathological effects of tuberculostatics an organism of laboratory animals. There was clear dose-dependence of SEMOP effects. The highest cytoprotective effect was observed at the SEMOP dose of 50 mg/kg. Antioxidant properties of SEMOP determined it membrane protective effects.
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Katikova O.J., Rusov V.I., Smirnov L.D. (2004) Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinat of the gepatotoxyc, caused at rats introduction тuberculostatics. Biomeditsinskaya Khimiya, 50(6), 600-604.
Katikova O.J. et al. Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinat of the gepatotoxyc, caused at rats introduction тuberculostatics // Biomeditsinskaya Khimiya. - 2004. - V. 50. -N 6. - P. 600-604.
Katikova O.J. et al., "Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinat of the gepatotoxyc, caused at rats introduction тuberculostatics." Biomeditsinskaya Khimiya 50.6 (2004): 600-604.
Katikova, O. J., Rusov, V. I., Smirnov, L. D. (2004). Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinat of the gepatotoxyc, caused at rats introduction тuberculostatics. Biomeditsinskaya Khimiya, 50(6), 600-604.
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