Studies on ecdysteroids: usage in medicine, internet-resources, sources, and biological activity

Timofeev N.P.1

1. “BIO”; Koryazhma, Russia
Section: Experimental/Clinical Study
Year: 2004
In this paper, the actual level of scientific investigations on ecdysteroids is reviewed representing a promising and rapidly developing area of biomedical chemistry: fields of application, medical importance, major representatives, sources, and biological activity. Historical retrospection views and the achieved research levels are shown while the world flora screening, identification of most active formulas, and study of practical application possibilities. The Internet-resources (data bases, volume, availability) at electronic libraries, search servers are analyzed for fundamental investigations and applied now-how, commercial offers. Basic sources and biotechnological methods of production of the major representatives of ecdysteroids – ponasterone, muristerone, and ecdysterone are surveyed. It is emphasized that chemically isolated ecdysteroids are extremely expensive and asked for mainly in science intensive investigations. To satisfy the mass demand for ecdysteroids in the pharmaceutical industry, non-purified or weakly purified plant formulations from super producer species with null toxicity rate that do not require high-expensive processing technologies have good prospects. In the case of Russia, cultivating Rhaponticum and Serratula plants representing super concentrator plant species is economically sound. The basic ecdysterone concentrations in plants of Rhaponticum carthamoides (Willd.) Iljin and Serratula coronata L. comprise 0.12-0.57 % and 0.31-1.15 % dry weight, respectively. Regarding the former species, there has appeared an industrial growing technology and a new class of pharmaceutical preparations from its aboveground shoots is being developed. The effective biological activity rate of extracts from Rhaponticum carthamoides grown with a special technology in agropopulations accounts for 10-11…10-13 M, that is 3-4 orders of magnitude higher than the activity rate of highly purified individual ecdysteroids (0,5-10 g/kg against 5-50 mg/kg).
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Timofeev, N. P. (2004). Studies on ecdysteroids: usage in medicine, internet-resources, sources, and biological activity . Biomeditsinskaya Khimiya, 50(application 1), 133-152.
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