Computer search and analysis of synaptonemal complex proteins in nematode Caenorhabditis elegans

   
Grishaeva T.M.1 , Dadashev S.Ya.1, Bogdanov Yu.F.1

1. Vavilov Institute of General Genetics RAS
Section: Experimental/Clinical Study
Year: 2004
Proteome of nematode Caenorhabditis elegans was analyzed by the use of original strategy of computer search for the structural proteins of synaptonemal complex (SC) in evolutionarily distant organisms. Analogs of the known SC proteins in other organisms - SCP1 and Zip1 - have been used as the models. The comparison in silico of these proteins with either the SC proteins revealed experimentally in C.elegans or putative ones annotated in databases, permit us to choose the most probable candidates for the proteins of SC transverse filaments in this nematode. Taking into account the peculiarities of SC ultrastructure in C.elegans we may state that molecules of the putative protein Q11102 can form uninterrupted transverse filaments passing from one SC lateral element to another
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Grishaeva, T. M., Dadashev, S. Ya., Bogdanov, Yu. F. (2004). Computer search and analysis of synaptonemal complex proteins in nematode Caenorhabditis elegans. Biomeditsinskaya khimiya, 50(application 1), 3-11.
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