An approach for selection of substances with specified metabolic properties

   
Pogrebnoy A.A.1 , Ryabinin V.E.1, Potemkin V.A.2, Bartashevich E.V.2, Grishina M.A.2

1. Chelyabinsk state medical academy
2. Chelyabinsk state university
Section: Experimental/Clinical Study
Year: 2004
An approach allowing to perform the preliminary selection of substances with specified metabolic properties is offered. The approach includes the classification of substances using 3D-QSAR algorithm BiS. It allows to fulfil the selection of substances being and not being P450 isoforms substrates depending on requirements. The same selection of substances can be required for the search of the drug candidates with specified metabolic properties in addition to the main pharmacological effect
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Pogrebnoy, A. A., Ryabinin, V. E., Potemkin, V. A., Bartashevich, E. V., Grishina, M. A. (2004). An approach for selection of substances with specified metabolic properties. Biomeditsinskaya khimiya, 50(application 1), 77-84.
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