Aurora B, Which is important for cell division control, is highly expressed in large number of cancer cell lines. Hesperadin, a prototype of a pharmacological agent, is a small molecule inhibitor of catalytic activity of Aurora B. In present work we investigate effect of Hesperadin on breast – MCF7 and prostate adenocarcioma – PC3, cancer cell lines. After Hesperadin treatment we observe stop of cell proliferation due to appearance of multiple mitotic defects caused by Aurora B. Activity reduction and elimination of checkpoint proteins – such as hBUBR1 and CENP-E – fron kinotochores of mitotic chromosomes/
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Ladygina N.G., Lacis R.V., Yen T. (2005) Effects of small molecule hesperadin on breast and prostate cancer cell lines. Biomeditsinskaya Khimiya, 51(2), 170-176.
Ladygina N.G. et al. Effects of small molecule hesperadin on breast and prostate cancer cell lines // Biomeditsinskaya Khimiya. - 2005. - V. 51. -N 2. - P. 170-176.
Ladygina N.G. et al., "Effects of small molecule hesperadin on breast and prostate cancer cell lines." Biomeditsinskaya Khimiya 51.2 (2005): 170-176.
Ladygina, N. G., Lacis, R. V., Yen, T. (2005). Effects of small molecule hesperadin on breast and prostate cancer cell lines. Biomeditsinskaya Khimiya, 51(2), 170-176.
References
Adams R.R., М. Carmena, and Earnshaw W.C. (2001) Trends Cell Biol., 11(2) , 49-54. Scholar google search
Hirota Т., Kunitoku N., Sasayama Т., Marumoto Т., Zhang D. (2003) Cell, 114, 585-598. Scholar google search
Adams R.R., Helatley W.S., Gouldsworthy A.M., Kandels-Lewis S.E., Carmena M., et.al. (2000) Curr. Biol, 10, 1075-1078. Scholar google search
Carmena M., Earnshaw W.C. (2003) Nat. Rev. Mol. Cell Biol., 4, 842-854. Scholar google search
Bischoff J.R., Anderson A.L., Zhu Y., Mossie K., Ng L., et. al. (1998) EMBO, 17, 3052-3065. Scholar google search
Hauf S., Cole R.W., LaTerra S., Zimmer C., Schnapp G. (2003) J. Cell Biol., 161, 281-294. Scholar google search
Chan O.K., Jablonski S.A., Svdakin V., Hittle J.C., Yen T.J. (1999) J. Cell. Biol., 146, 941-954. Scholar google search
Adams R.R., Maiato I.I., Earnshaw W.C., Carmena M. (2001) J Cell Biol., 153, 865-880. Scholar google search
Jedrusik M.A.and Schulze E. (2004) Methods Mol. Biol., 254, 35-48. Scholar google search
Ditchfield C., Johnson V.L., Tighe A., Elision R., Haworth С. (2003) J. Cell Biol., 161, 267-280. Scholar google search
Schaar B.T., Chan G.K.T., Maddox R., Salmon E.D., Yen T. (1997) J Cell Biol., 139, 1373-1382. Scholar google search
