Effects of small molecule hesperadin on breast and prostate cancer cell lines

   
Ladygina N.G.1 , Lacis R.V.2 , Yen T.3

1. Russian State Medical University, Fox Chase Cancer Center
2. Russian State Medical University
3. Fox Chase Cancer Center
Section: Experimental/Clinical Study
PubMed Id: 15945350
Year: 2005  Volume: 51  Issue: 2  Pages: 170-176
Aurora B, Which is important for cell division control, is highly expressed in large number of cancer cell lines. Hesperadin, a prototype of a pharmacological agent, is a small molecule inhibitor of catalytic activity of Aurora B. In present work we investigate effect of Hesperadin on breast – MCF7 and prostate adenocarcioma – PC3, cancer cell lines. After Hesperadin treatment we observe stop of cell proliferation due to appearance of multiple mitotic defects caused by Aurora B. Activity reduction and elimination of checkpoint proteins – such as hBUBR1 and CENP-E – fron kinotochores of mitotic chromosomes/
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Ladygina N.G., Lacis R.V., Yen T. (2005) Biomeditsinskaya khimiya, 51(2), 170-176.
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