Antioxidant enzymes of rat liver, brain, heart and erythrocyte in ammonia intoxication

   
Venediktova N.I.1, Lopata O.V.1, Pogosyan A.S.1, Kosenko E.A.1, Kaminsky Yu.G.1

1. Institute of Theoretical and Experimental Biophysics RAS, Pushchino
Section: Experimental/Clinical Study
PubMed Id: 15945352
Year: 2005  Volume: 51  Issue: 2  Pages: 185-191
Injection of large amounts of ammonium salts leads to rapid death of animals. However, the molecular mechanisms involved in ammonia toxicity remain to be clarified. We have tested the effect of toxic dose of ammonium acetate on the activities of antioxidant enzymes in rat liver, brain, heart and erythrocytes. Acute ammonia intoxication resulted in rapid (within 11 min) decrease in superoxide dismutase, catalase and gluthatione peroxidase activities in liver and brain mitochondria and cytosol and in erythrocytes, but in increase of these enzyme activities in heart. Diminished activities of the antioxidant enzymes in liver, brain erythrocytes suggest that the systemic oxidative stress takes place, whereas their elevated activities in heart can be the adaptive reaction to oxidative stress in hyperammoniemia.
Download PDF:
Reference:

Venediktova N.I., Lopata O.V., Pogosyan A.S., Kosenko E.A., Kaminsky Yu.G. (2005) Biomeditsinskaya khimiya, 51(2), 185-191.
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)